mTOR Inhibition Elicits a Dramatic Response in PI3K-Dependent Colon Cancers

The phosphatidylinositide-3-kinase (PI3K) signaling pathway is critical for multiple cellular functions including metabolism, proliferation, angiogenesis, and apoptosis, and is the most commonly altered pathway in human cancers. Recently, we developed a novel mouse model of colon cancer in which tum...

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Autors principals: Deming, Dustin A., Leystra, Alyssa A., Farhoud, Mohammed, Nettekoven, Laura, Clipson, Linda, Albrecht, Dawn, Washington, Mary Kay, Sullivan, Ruth, Weichert, Jamey P., Halberg, Richard B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621889/
https://ncbi.nlm.nih.gov/pubmed/23593290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060709
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