Mice Expressing Activated PI3K Rapidly Develop Advanced Colon Cancer

Aberrations in the phosphatidylinositide-3-kinase (PI3K) signaling pathway play a key role in the pathogenesis of numerous cancers by altering cellular growth, metabolism, proliferation, and apoptosis (1). Mutations in the catalytic domain of PI3K that generate a dominantly active kinase are commonl...

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Bibliographic Details
Main Authors: Leystra, Alyssa A., Deming, Dustin A., Zahm, Christopher D., Farhoud, Mohammed, Paul Olson, Terrah J., Hadac, Jamie N., Nettekoven, Laura A., Albrecht, Dawn M., Clipson, Linda, Sullivan, Ruth, Washington, Mary Kay, Torrealba, Jose R., Weichert, Jamey P., Halberg, Richard B.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645915/
https://ncbi.nlm.nih.gov/pubmed/22525701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-4097
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