Mice Expressing Activated PI3K Rapidly Develop Advanced Colon Cancer

Aberrations in the phosphatidylinositide-3-kinase (PI3K) signaling pathway play a key role in the pathogenesis of numerous cancers by altering cellular growth, metabolism, proliferation, and apoptosis (1). Mutations in the catalytic domain of PI3K that generate a dominantly active kinase are commonl...

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Detalhes bibliográficos
Main Authors: Leystra, Alyssa A., Deming, Dustin A., Zahm, Christopher D., Farhoud, Mohammed, Paul Olson, Terrah J., Hadac, Jamie N., Nettekoven, Laura A., Albrecht, Dawn M., Clipson, Linda, Sullivan, Ruth, Washington, Mary Kay, Torrealba, Jose R., Weichert, Jamey P., Halberg, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645915/
https://ncbi.nlm.nih.gov/pubmed/22525701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-4097
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