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Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in Drosophila

Axon degeneration is observed at the early stages of many neurodegenerative conditions and this often leads to subsequent neuronal loss. We previously showed that inactivating the c-Jun N-terminal kinase (JNK) pathway leads to axon degeneration in Drosophila mushroom body (MB) neurons. To understand...

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Detalhes bibliográficos
Main Authors: Rallis, Andrew, Lu, Bingwei, Ng, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619812/
https://ncbi.nlm.nih.gov/pubmed/23264732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.117259
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