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Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in Drosophila

Axon degeneration is observed at the early stages of many neurodegenerative conditions and this often leads to subsequent neuronal loss. We previously showed that inactivating the c-Jun N-terminal kinase (JNK) pathway leads to axon degeneration in Drosophila mushroom body (MB) neurons. To understand...

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Hlavní autoři: Rallis, Andrew, Lu, Bingwei, Ng, Julian
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619812/
https://ncbi.nlm.nih.gov/pubmed/23264732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.117259
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