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Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in Drosophila

Axon degeneration is observed at the early stages of many neurodegenerative conditions and this often leads to subsequent neuronal loss. We previously showed that inactivating the c-Jun N-terminal kinase (JNK) pathway leads to axon degeneration in Drosophila mushroom body (MB) neurons. To understand...

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Autors principals: Rallis, Andrew, Lu, Bingwei, Ng, Julian
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619812/
https://ncbi.nlm.nih.gov/pubmed/23264732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.117259
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