Rational reprogramming of fungal polyketide first-ring cyclization

Resorcylic acid lactones and dihydroxyphenylacetic acid lactones represent important pharmacophores with heat shock response and immune system modulatory activities. The biosynthesis of these fungal polyketides involves a pair of collaborating iterative polyketide synthases (iPKSs): a highly reducin...

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Bibliografiske detaljer
Main Authors: Xu, Yuquan, Zhou, Tong, Zhou, Zhengfu, Su, Shiyou, Roberts, Sue A., Montfort, William R., Zeng, Jia, Chen, Ming, Zhang, Wei, Lin, Min, Zhan, Jixun, Molnár, István
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619332/
https://ncbi.nlm.nih.gov/pubmed/23509261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301201110
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