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Rational reprogramming of fungal polyketide first-ring cyclization
Resorcylic acid lactones and dihydroxyphenylacetic acid lactones represent important pharmacophores with heat shock response and immune system modulatory activities. The biosynthesis of these fungal polyketides involves a pair of collaborating iterative polyketide synthases (iPKSs): a highly reducin...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3619332/ https://ncbi.nlm.nih.gov/pubmed/23509261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301201110 |
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