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Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure
The serotonin receptor 2C plays a central role in mood and appetite control. It undergoes pre-mRNA editing as well as alternative splicing. The RNA editing suggests that the pre-mRNA forms a stable secondary structure in vivo. To identify substances that promote alternative exons inclusion, we set u...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3616728/ https://ncbi.nlm.nih.gov/pubmed/23393189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt063 |
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