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Oligonucleotide‐induced alternative splicing of serotonin 2C receptor reduces food intake

The serotonin 2C receptor regulates food uptake, and its activity is regulated by alternative pre‐mRNA splicing. Alternative exon skipping is predicted to generate a truncated receptor protein isoform, whose existence was confirmed with a new antiserum. The truncated receptor sequesters the full‐len...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Zhang, Zhaiyi, Shen, Manli, Gresch, Paul J, Ghamari‐Langroudi, Masoud, Rabchevsky, Alexander G, Emeson, Ronald B, Stamm, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967942/
https://ncbi.nlm.nih.gov/pubmed/27406820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201506030
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