The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer

WNT signaling plays a key role in the self-renewal of tumor initiation cells (TICs). In this study, we used pyrvinium pamoate (PP), an FDA-approved antihelmintic drug that inhibits WNT signaling, to test whether pharmacologic inhibition of WNT signaling can specifically target TICs of aggressive bre...

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Bibliografski detalji
Glavni autori: Xu, Wei, Lacerda, Lara, Debeb, Bisrat G., Atkinson, Rachel L., Solley, Travis N., Li, Li, Orton, Darren, McMurray, John S., Hang, Brian I., Lee, Ethan, Klopp, Ann H., Ueno, Naoto T., Reuben, James M., Krishnamurthy, Savitri, Woodward, Wendy A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754994/
https://ncbi.nlm.nih.gov/pubmed/24013655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071508
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