The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer

WNT signaling plays a key role in the self-renewal of tumor initiation cells (TICs). In this study, we used pyrvinium pamoate (PP), an FDA-approved antihelmintic drug that inhibits WNT signaling, to test whether pharmacologic inhibition of WNT signaling can specifically target TICs of aggressive bre...

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Detalles Bibliográficos
Main Authors: Xu, Wei, Lacerda, Lara, Debeb, Bisrat G., Atkinson, Rachel L., Solley, Travis N., Li, Li, Orton, Darren, McMurray, John S., Hang, Brian I., Lee, Ethan, Klopp, Ann H., Ueno, Naoto T., Reuben, James M., Krishnamurthy, Savitri, Woodward, Wendy A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754994/
https://ncbi.nlm.nih.gov/pubmed/24013655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071508
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