Histone Deacetylase Inhibitors Stimulate Dedifferentiation of Human Breast Cancer Cells through WNT/β-catenin Signaling

Recent studies have shown that differentiated cancer cells can de-differentiate into cancer stem cells (CSCs) although to date no studies have reported whether this transition is influenced by systemic anti-cancer agents. Valproic acid (VA) is a histone deacetylase (HDAC) inhibitor that promotes sel...

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Bibliographic Details
Published in:Stem Cells
Main Authors: Debeb, Bisrat G, Lacerda, Lara, Xu, Wei, Larson, Richard, Solley, Travis, Atkinson, Rachel, Sulman, Erik P., Ueno, Naoto T, Krishnamurthy, Savitri, Reuben, James M, Buchholz, Thomas A, Woodward, Wendy A
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545658/
https://ncbi.nlm.nih.gov/pubmed/22961641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1219
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