The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer

WNT signaling plays a key role in the self-renewal of tumor initiation cells (TICs). In this study, we used pyrvinium pamoate (PP), an FDA-approved antihelmintic drug that inhibits WNT signaling, to test whether pharmacologic inhibition of WNT signaling can specifically target TICs of aggressive bre...

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Hlavní autoři: Xu, Wei, Lacerda, Lara, Debeb, Bisrat G., Atkinson, Rachel L., Solley, Travis N., Li, Li, Orton, Darren, McMurray, John S., Hang, Brian I., Lee, Ethan, Klopp, Ann H., Ueno, Naoto T., Reuben, James M., Krishnamurthy, Savitri, Woodward, Wendy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754994/
https://ncbi.nlm.nih.gov/pubmed/24013655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071508
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