Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure

The serotonin receptor 2C plays a central role in mood and appetite control. It undergoes pre-mRNA editing as well as alternative splicing. The RNA editing suggests that the pre-mRNA forms a stable secondary structure in vivo. To identify substances that promote alternative exons inclusion, we set u...

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Autors principals: Shen, Manli, Bellaousov, Stanislav, Hiller, Michael, de La Grange, Pierre, Creamer, Trevor P., Malina, Orit, Sperling, Ruth, Mathews, David H., Stoilov, Peter, Stamm, Stefan
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
RNA
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616728/
https://ncbi.nlm.nih.gov/pubmed/23393189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt063
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