Differential Type I Interferon-dependent Transgene Silencing of Helper-dependent Adenoviral vs. Adeno-associated Viral Vectors In Vivo

We previously dissected the components of the innate immune response to Helper-dependent adenoviral vectors (HDAds) using genetic models, and demonstrated that multiple pattern recognition receptor signaling pathways contribute to this host response to HDAds in vivo. Based on analysis of cytokine ex...

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Main Authors: Suzuki, Masataka, Bertin, Terry K, Rogers, Geoffrey L, Cela, Racel G, Zolotukhin, Irene, Palmer, Donna J, Ng, Philip, Herzog, Roland W, Lee, Brendan
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616533/
https://ncbi.nlm.nih.gov/pubmed/23319058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.277
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