MyD88-Dependent Silencing of Transgene Expression During the Innate and Adaptive Immune Response to Helper-Dependent Adenovirus

Activation of the host innate immune response after systemic administration of adenoviral vectors constitutes a principal impediment to successful clinical gene replacement therapies. Although helper-dependent adenoviruses (HDAds) lack all viral functional genes, systemic administration of a high do...

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Bibliographic Details
Main Authors: Suzuki, Masataka, Cerullo, Vincenzo, Bertin, Terry K., Cela, Racel, Clarke, Christian, Guenther, Margaretha, Brunetti-Pierri, Nicola, Lee, Brendan
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2010
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865218/
https://ncbi.nlm.nih.gov/pubmed/19824822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2009.155
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