Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy

Phospholipase Cε (PLCε) is a multifunctional enzyme implicated in cardiovascular, pancreatic and inflammatory functions. Here we show that conditional deletion of PLCε in mouse cardiac myocytes protects from stress-induced pathological hypertrophy. PLCε siRNA in ventricular myocytes decreases endoth...

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Main Authors: Zhang, Lianghui, Malik, Sundeep, Pang, Jinjiang, Wang, Huan, Park, Keigan M., Yule, David I., Blaxall, Burns C., Smrcka, Alan V.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615249/
https://ncbi.nlm.nih.gov/pubmed/23540699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.02.047
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