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Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production
Phospholipase C (PLC) enzymes hydrolyze the plasma membrane (PM) lipid phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) to generate the second messengers inositol trisphosphate (IP(3)) and diacylglycerol (DAG) in response to receptor activation in almost all mammalian cells. We previously found tha...
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| Publicado no: | Sci Signal |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6413320/ https://ncbi.nlm.nih.gov/pubmed/30206135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aan1210 |
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