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Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy
Phospholipase Cε (PLCε) is a multifunctional enzyme implicated in cardiovascular, pancreatic and inflammatory functions. Here we show that conditional deletion of PLCε in mouse cardiac myocytes protects from stress-induced pathological hypertrophy. PLCε siRNA in ventricular myocytes decreases endoth...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3615249/ https://ncbi.nlm.nih.gov/pubmed/23540699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.02.047 |
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