Structural Landscape of the Proline-Rich Domain of Sos1 Nucleotide Exchange Factor

Despite its key role in mediating a plethora of cellular signaling cascades pertinent to health and disease, little is known about the structural landscape of the proline-rich (PR) domain of Sos1 guanine nucleotide exchange factor. Herein, using a battery of biophysical tools, we provide evidence th...

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Bibliographic Details
Main Authors: McDonald, Caleb B., Bhat, Vikas, Kurouski, Dmitry, Mikles, David C., Deegan, Brian J., Seldeen, Kenneth L., Lednev, Igor K., Farooq, Amjad
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615079/
https://ncbi.nlm.nih.gov/pubmed/23528987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpc.2013.02.008
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