Multivalent Binding and Facilitated Diffusion Account for the Formation of Grb2-Sos1 Signaling Complex in a Cooperative Manner

Despite its key role in driving cellular growth and proliferation through receptor tyrosine kinase (RTK) signaling, the Grb2-Sos1 macromolecular interaction remains poorly understood in mechanistic terms. Herein, using an array of biophysical methods, we provide evidence that although Grb2 adaptor c...

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Hlavní autoři: McDonald, Caleb B., Balke, Jordan E., Bhat, Vikas, Mikles, David C., Deegan, Brian J., Seldeen, Kenneth L., Farooq, Amjad
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303612/
https://ncbi.nlm.nih.gov/pubmed/22360309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3000534
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