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Multivalent Binding and Facilitated Diffusion Account for the Formation of Grb2-Sos1 Signaling Complex in a Cooperative Manner
Despite its key role in driving cellular growth and proliferation through receptor tyrosine kinase (RTK) signaling, the Grb2-Sos1 macromolecular interaction remains poorly understood in mechanistic terms. Herein, using an array of biophysical methods, we provide evidence that although Grb2 adaptor c...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3303612/ https://ncbi.nlm.nih.gov/pubmed/22360309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3000534 |
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