Bivalent Binding Drives the Formation of Grb2-Gab1 Signaling Complex in a Non-Cooperative Manner

Although Grb2-Gab1 macromolecular complex mediates a multitude of cellular signaling cascades, the molecular basis of its assembly remains hitherto largely elusive. Herein, using an array of biophysical techniques, we show that while Grb2 exists in a monomer-dimer equilibrium, the proline-rich (PR)...

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Detalhes bibliográficos
Main Authors: McDonald, Caleb B., Bhat, Vikas, Mikles, David C., Deegan, Brian J., Seldeen, Kenneth L., Farooq, Amjad
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365654/
https://ncbi.nlm.nih.gov/pubmed/22536782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2012.08600.x
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