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Bivalent Binding Drives the Formation of Grb2-Gab1 Signaling Complex in a Non-Cooperative Manner
Although Grb2-Gab1 macromolecular complex mediates a multitude of cellular signaling cascades, the molecular basis of its assembly remains hitherto largely elusive. Herein, using an array of biophysical techniques, we show that while Grb2 exists in a monomer-dimer equilibrium, the proline-rich (PR)...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3365654/ https://ncbi.nlm.nih.gov/pubmed/22536782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2012.08600.x |
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