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SH3 Domains of Grb2 Adaptor Bind to PXψPXR Motifs Within the Sos1 Nucleotide Exchange Factor in a Discriminate Manner

Ubiquitously encountered in a wide variety of cellular processes, the Grb2-Sos1 interaction is mediated through the combinatorial binding of nSH3 and cSH3 domains of Grb2 to various sites containing PXψPXR motifs within Sos1. Here, using isothermal titration calorimetry, we demonstrate that while th...

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Bibliografiset tiedot
Päätekijät: McDonald, Caleb B., Seldeen, Kenneth L., Deegan, Brian J., Farooq, Amjad
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710136/
https://ncbi.nlm.nih.gov/pubmed/19323566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802291y
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