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Allostery Mediates Ligand Binding to Grb2 Adaptor in a Mutually Exclusive Manner
Allostery plays a key role in dictating the stoichiometry and thermodynamics of multi-protein complexes driving a plethora of cellular processes central to health and disease. Herein, using various biophysical tools, we demonstrate that although Sos1 nucleotide exchange factor and Gab1 docking prote...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557811/ https://ncbi.nlm.nih.gov/pubmed/23334917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmr.2256 |
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