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Energetic Coupling Along an Allosteric Communication Channel Drives the Binding of Jun-Fos Heterodimeric Transcription Factor to DNA
Although allostery plays a central role in driving protein-DNA interactions, the physical basis of such cooperative behavior remains poorly understood. Herein, using isothermal titration calorimetry in conjunction with site-directed mutagenesis, we provide evidence that an intricate network of energ...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3154423/ https://ncbi.nlm.nih.gov/pubmed/21496208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2011.08124.x |
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