Integrative screening approach identifies regulators of polyploidization and targets for acute megakaryocytic leukemia

The mechanism by which cells decide to skip mitosis to become polyploid is largely undefined. Here we used a high-content image-based screen to identify small-molecule probes that induce polyploidization of megakaryocytic leukemia cells and serve as perturbagens to help understand this process. We f...

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Detalhes bibliográficos
Main Authors: Wen, Qiang, Goldenson, Benjamin, Silver, Serena J., Schenone, Monica, Dancik, Vladimir, Huang, Zan, Wang, Ling-Zhi, Lewis, Timothy, An, W. Frank, Li, Xiaoyu, Bray, Mark-Anthony, Thiollier, Clarisse, Diebold, Lauren, Gilles, Laure, Vokes, Martha S., Moore, Christopher B., Bliss-Moreau, Meghan, VerPlank, Lynn, Tolliday, Nicola J., Mishra, Rama, Vemula, Sasidhar, Shi, Jianjian, Wei, Lei, Kapur, Reuben, Lopez, Cécile K., Gerby, Bastien, Ballerini, Paola, Pflumio, Francoise, Gilliland, D. Gary, Goldberg, Liat, Birger, Yehudit, Izraeli, Shai, Gamis, Alan S., Smith, Franklin O., Woods, William G., Taub, Jeffrey, Scherer, Christina A., Bradner, James, Goh, Boon-Cher, Mercher, Thomas, Carpenter, Anne E., Gould, Robert J., Clemons, Paul A., Carr, Steven A., Root, David E., Schreiber, Stuart L., Stern, Andrew M., Crispino, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613864/
https://ncbi.nlm.nih.gov/pubmed/22863010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.032
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