Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.

The transforming gene product of avian erythroblastosis virus, v-erbB, is derived from the epidermal growth factor (EGF) receptor but has lost its extracellular ligand-binding domain and was mutated in its cytoplasmic portion, which is thought to be responsible for biological signal generation. We h...

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Hlavní autoři: Massoglia, S, Gray, A, Dull, T J, Munemitsu, S, Kun, H J, Schlessinger, J, Ullrich, A
Médium: Artigo
Jazyk:Inglês
Vydáno: 1990
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC360669/
https://ncbi.nlm.nih.gov/pubmed/1971419
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