Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.

The transforming gene product of avian erythroblastosis virus, v-erbB, is derived from the epidermal growth factor (EGF) receptor but has lost its extracellular ligand-binding domain and was mutated in its cytoplasmic portion, which is thought to be responsible for biological signal generation. We h...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: Massoglia, S, Gray, A, Dull, T J, Munemitsu, S, Kun, H J, Schlessinger, J, Ullrich, A
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360669/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1971419/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.6.3048
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