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Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.

The transforming gene product of avian erythroblastosis virus, v-erbB, is derived from the epidermal growth factor (EGF) receptor but has lost its extracellular ligand-binding domain and was mutated in its cytoplasmic portion, which is thought to be responsible for biological signal generation. We h...

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Detalhes bibliográficos
Main Authors: Massoglia, S, Gray, A, Dull, T J, Munemitsu, S, Kun, H J, Schlessinger, J, Ullrich, A
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC360669/
https://ncbi.nlm.nih.gov/pubmed/1971419
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