Epidermal growth factor receptor cytoplasmic domain mutations trigger ligand-independent transformation.

The transforming gene product of avian erythroblastosis virus, v-erbB, is derived from the epidermal growth factor (EGF) receptor but has lost its extracellular ligand-binding domain and was mutated in its cytoplasmic portion, which is thought to be responsible for biological signal generation. We h...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Massoglia, S, Gray, A, Dull, T J, Munemitsu, S, Kun, H J, Schlessinger, J, Ullrich, A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1971419/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.6.3048-3055.1990
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