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Overexpression of Kinase Suppressor of Ras Upregulates the High-Molecular-Weight Tropomyosin Isoforms in ras-Transformed NIH 3T3 Fibroblasts

The down-regulation of the high-molecular-weight isoforms of tropomyosin (TM) is considered to be an essential event in cellular transformation. In ras-transformed fibroblasts, the suppression of TM is dependent on the activity of the Raf-1 kinase; however, the requirement for other downstream effec...

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Main Authors: Janssen, Richard A. J., Kim, Phillia N., Mier, James W., Morrison, Deborah K.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2003
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC151698/
https://ncbi.nlm.nih.gov/pubmed/12588996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.5.1786-1797.2003
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