NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels

BACKGROUND AND PURPOSE: Overactive bladder (OAB) is often associated with abnormally increased detrusor smooth muscle (DSM) contractions. We used NS309, a selective and potent opener of the small or intermediate conductance Ca(2+)-activated K(+) (SK or IK, respectively) channels, to evaluate how SK/...

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Main Authors: Parajuli, Shankar P, Hristov, Kiril L, Soder, Rupal P, Kellett, Whitney F, Petkov, Georgi V
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2013
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Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605870/
https://ncbi.nlm.nih.gov/pubmed/23145946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12049
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