SK channel-selective opening by SKA-31 induces hyperpolarization and decreases contractility in human urinary bladder smooth muscle

Overactive bladder (OAB) is often associated with increased involuntary detrusor smooth muscle (DSM) contractions during the bladder-filling phase. To develop novel therapies for OAB, it is critical to better understand the mechanisms that control DSM excitability and contractility. Recent studies s...

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Bibliographic Details
Main Authors: Soder, Rupal P., Parajuli, Shankar P., Hristov, Kiril L., Rovner, Eric S., Petkov, Georgi V.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
Subjects:
Cardiovascular and Renal Integration
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543661/
https://ncbi.nlm.nih.gov/pubmed/23174857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00363.2012
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