Pharmacological Activation of Small Conductance Calcium-Activated Potassium Channels with Naphtho[1,2-d]thiazol-2-ylamine Decreases Guinea Pig Detrusor Smooth Muscle Excitability and Contractility

Small conductance Ca(2+)-activated K(+) (SK) and intermediate conductance Ca(2+)-activated K(+) (IK) channels are thought to be involved in detrusor smooth muscle (DSM) excitability and contractility. Using naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a novel and highly specific SK/IK channel activator...

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Bibliografiset tiedot
Päätekijät: Parajuli, Shankar P., Soder, Rupal P., Hristov, Kiril L., Petkov, Georgi V.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2012
Aiheet:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251021/
https://ncbi.nlm.nih.gov/pubmed/22001258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.186213
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