Allosteric Inhibition of Hypoxia Inducible Factor-2 with Small Molecules

Hypoxia Inducible Factors (HIFs) are heterodimeric transcription factors induced in many cancers where they frequently promote the expression of many protumorigenic pathways. Though transcription factors are typically considered “undruggable”, the PAS-B domain of the HIF-2α subunit contains a large...

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Bibliografski detalji
Glavni autori: Scheuermann, Thomas H, Li, Qiming, Ma, He-Wen, Key, Jason, Zhang, Lei, Chen, Rui, Garcia, Joseph A, Naidoo, Jacinth, Longgood, Jamie, Frantz, Doug E, Tambar, Uttam K, Gardner, Kevin H, Bruick, Richard K
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604136/
https://ncbi.nlm.nih.gov/pubmed/23434853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1185
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