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Allosteric control of the ribosome by small-molecule antibiotics

Protein synthesis is targeted by numerous, chemically distinct antibiotics that bind and inhibit key functional centers of the ribosome. Using single-molecule imaging and X-ray crystallography, we show that the aminoglycoside neomycin blocks aminoacyl–transfer RNA (aa-tRNA) selection and translocati...

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Autors principals: Wang, Leyi, Pulk, Arto, Wasserman, Michael R, Feldman, Michael B, Altman, Roger B, Cate, Jamie H. Doudna, Blanchard, Scott C
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645490/
https://ncbi.nlm.nih.gov/pubmed/22902368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2360
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