Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions

Dynamic remodelling of intersubunit bridge B2, a conserved RNA domain of the bacterial ribosome connecting helices 44 (h44) and 69 (H69) of the small and large subunit, respectively, impacts translation by controlling intersubunit rotation. Here we show that aminoglycosides chemically related to neo...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Wasserman, Michael R., Pulk, Arto, Zhou, Zhou, Altman, Roger B., Zinder, John C., Green, Keith D., Garneau-Tsodikova, Sylvie, Doudna Cate, Jamie H., Blanchard, Scott C.
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522699/
https://ncbi.nlm.nih.gov/pubmed/26224058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8896
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