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Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions
Dynamic remodelling of intersubunit bridge B2, a conserved RNA domain of the bacterial ribosome connecting helices 44 (h44) and 69 (H69) of the small and large subunit, respectively, impacts translation by controlling intersubunit rotation. Here we show that aminoglycosides chemically related to neo...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Pub. Group
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4522699/ https://ncbi.nlm.nih.gov/pubmed/26224058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8896 |
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