Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions

Dynamic remodelling of intersubunit bridge B2, a conserved RNA domain of the bacterial ribosome connecting helices 44 (h44) and 69 (H69) of the small and large subunit, respectively, impacts translation by controlling intersubunit rotation. Here we show that aminoglycosides chemically related to neo...

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Pubblicato in:Nat Commun
Autori principali: Wasserman, Michael R., Pulk, Arto, Zhou, Zhou, Altman, Roger B., Zinder, John C., Green, Keith D., Garneau-Tsodikova, Sylvie, Doudna Cate, Jamie H., Blanchard, Scott C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522699/
https://ncbi.nlm.nih.gov/pubmed/26224058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8896
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