Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions

Dynamic remodelling of intersubunit bridge B2, a conserved RNA domain of the bacterial ribosome connecting helices 44 (h44) and 69 (H69) of the small and large subunit, respectively, impacts translation by controlling intersubunit rotation. Here we show that aminoglycosides chemically related to neo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Wasserman, Michael R., Pulk, Arto, Zhou, Zhou, Altman, Roger B., Zinder, John C., Green, Keith D., Garneau-Tsodikova, Sylvie, Doudna Cate, Jamie H., Blanchard, Scott C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Pub. Group 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522699/
https://ncbi.nlm.nih.gov/pubmed/26224058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8896
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