Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions

Dynamic remodelling of intersubunit bridge B2, a conserved RNA domain of the bacterial ribosome connecting helices 44 (h44) and 69 (H69) of the small and large subunit, respectively, impacts translation by controlling intersubunit rotation. Here we show that aminoglycosides chemically related to neo...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Wasserman, Michael R., Pulk, Arto, Zhou, Zhou, Altman, Roger B., Zinder, John C., Green, Keith D., Garneau-Tsodikova, Sylvie, Doudna Cate, Jamie H., Blanchard, Scott C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Pub. Group 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522699/
https://ncbi.nlm.nih.gov/pubmed/26224058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8896
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