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Allosteric control of the ribosome by small-molecule antibiotics
Protein synthesis is targeted by numerous, chemically distinct antibiotics that bind and inhibit key functional centers of the ribosome. Using single-molecule imaging and X-ray crystallography, we show that the aminoglycoside neomycin blocks aminoacyl–transfer RNA (aa-tRNA) selection and translocati...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3645490/ https://ncbi.nlm.nih.gov/pubmed/22902368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2360 |
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