Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

Hypoxia Inducible Factors (HIFs) are heterodimeric transcription factors induced in a variety of pathophysiological settings, including cancer. We describe the first detailed structure-activity-relationship study of small molecules designed to inhibit HIF-2α–ARNT heterodimerization by binding an int...

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主要な著者: Rogers, Jamie L., Bayeh, Liela, Scheuermann, Thomas H., Longgood, Jamie, Key, Jason, Naidoo, Jacinth, Melito, Lisa, Shokri, Cameron, Frantz, Doug E., Bruick, Richard K., Gardner, Kevin H., MacMillan, John B., Tambar, Uttam K.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676484/
https://ncbi.nlm.nih.gov/pubmed/23363003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301847z
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