Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

Hypoxia Inducible Factors (HIFs) are heterodimeric transcription factors induced in a variety of pathophysiological settings, including cancer. We describe the first detailed structure-activity-relationship study of small molecules designed to inhibit HIF-2α–ARNT heterodimerization by binding an int...

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Autors principals: Rogers, Jamie L., Bayeh, Liela, Scheuermann, Thomas H., Longgood, Jamie, Key, Jason, Naidoo, Jacinth, Melito, Lisa, Shokri, Cameron, Frantz, Doug E., Bruick, Richard K., Gardner, Kevin H., MacMillan, John B., Tambar, Uttam K.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676484/
https://ncbi.nlm.nih.gov/pubmed/23363003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301847z
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