Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor

The hypoxia-inducible factor (HIF) basic helix–loop–helix Per-aryl hydrocarbon receptor nuclear translocator (ARNT)-Sim (bHLH-PAS) transcription factors are master regulators of the conserved molecular mechanism by which metazoans sense and respond to reductions in local oxygen concentrations. In hu...

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Detalles Bibliográficos
Autores principales: Scheuermann, Thomas H., Tomchick, Diana R., Machius, Mischa, Guo, Yan, Bruick, Richard K., Gardner, Kevin H.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626723/
https://ncbi.nlm.nih.gov/pubmed/19129502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808092106
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