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Protein Dynamics of the HIF-2α PAS-B Domain upon Heterodimerization and Ligand Binding
Hypoxia-Inducible Factor (HIF) transcription factors are heterodimeric proteins involved in the regulation of oxygen homeostatis. Their upregulation has been related to several tumors with a remarkably poor clinical outcome. The recent discovery of a druggable cavity in the HIF-2α PAS-B domain has o...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3988133/ https://ncbi.nlm.nih.gov/pubmed/24736273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094986 |
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