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Principles of ligand binding within a completely buried cavity in HIF2α PAS-B
Hypoxia inducible factors (HIFs) are heterodimeric transcription factors responsible for the metazoan hypoxia response and are required for tumor growth, metastasis and resistance to cancer treatment. The C-terminal PAS domain of HIF2α (HIF2α PAS-B) contains a preformed solvent-inaccessible cavity t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2819816/ https://ncbi.nlm.nih.gov/pubmed/19950993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9073062 |
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