Principles of ligand binding within a completely buried cavity in HIF2α PAS-B

Hypoxia inducible factors (HIFs) are heterodimeric transcription factors responsible for the metazoan hypoxia response and are required for tumor growth, metastasis and resistance to cancer treatment. The C-terminal PAS domain of HIF2α (HIF2α PAS-B) contains a preformed solvent-inaccessible cavity t...

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Bibliographic Details
Main Authors:	Key, Jason, Scheuermann, Thomas H., Anderson, Peter C., Daggett, Valerie, Gardner, Kevin H.
Format:	Artigo
Language:	Inglês
Published:	2009
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2819816/ https://ncbi.nlm.nih.gov/pubmed/19950993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9073062
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Principles of ligand binding within a completely buried cavity in HIF2α PAS-B

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