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Homologous ligands accommodated by discrete conformations of a buried cavity
Conformational change in protein–ligand complexes is widely modeled, but the protein accommodation expected on binding a congeneric series of ligands has received less attention. Given their use in medicinal chemistry, there are surprisingly few substantial series of congeneric ligand complexes in t...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4413287/ https://ncbi.nlm.nih.gov/pubmed/25847998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500806112 |
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