Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

Hypoxia Inducible Factors (HIFs) are heterodimeric transcription factors induced in a variety of pathophysiological settings, including cancer. We describe the first detailed structure-activity-relationship study of small molecules designed to inhibit HIF-2α–ARNT heterodimerization by binding an int...

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Detalhes bibliográficos
Main Authors: Rogers, Jamie L., Bayeh, Liela, Scheuermann, Thomas H., Longgood, Jamie, Key, Jason, Naidoo, Jacinth, Melito, Lisa, Shokri, Cameron, Frantz, Doug E., Bruick, Richard K., Gardner, Kevin H., MacMillan, John B., Tambar, Uttam K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676484/
https://ncbi.nlm.nih.gov/pubmed/23363003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301847z
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