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A New Paradigm for GERD Pathogenesis: Not Acid Injury, But Cytokine-Mediated Inflammation Driven by HIF-2α: A Potential Role for Targeting HIF-2α to Prevent and Treat Reflux Esophagitis
Traditionally, reflux esophagitis was assumed to develop as a caustic, chemical injury inflicted by refluxed acid. Recently, however, studies in rats and humans suggest that reflux esophagitis develops as a cytokine-mediated inflammatory injury, with hypoxia inducible factor (HIF)-2α playing a major...
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| Published in: | Curr Opin Pharmacol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5922421/ https://ncbi.nlm.nih.gov/pubmed/29112883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coph.2017.10.004 |
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