Allosteric Inhibition of Hypoxia Inducible Factor-2 with Small Molecules

Hypoxia Inducible Factors (HIFs) are heterodimeric transcription factors induced in many cancers where they frequently promote the expression of many protumorigenic pathways. Though transcription factors are typically considered “undruggable”, the PAS-B domain of the HIF-2α subunit contains a large...

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Main Authors: Scheuermann, Thomas H, Li, Qiming, Ma, He-Wen, Key, Jason, Zhang, Lei, Chen, Rui, Garcia, Joseph A, Naidoo, Jacinth, Longgood, Jamie, Frantz, Doug E, Tambar, Uttam K, Gardner, Kevin H, Bruick, Richard K
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604136/
https://ncbi.nlm.nih.gov/pubmed/23434853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1185
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