Allosteric Inhibition of Hypoxia Inducible Factor-2 with Small Molecules

Hypoxia Inducible Factors (HIFs) are heterodimeric transcription factors induced in many cancers where they frequently promote the expression of many protumorigenic pathways. Though transcription factors are typically considered “undruggable”, the PAS-B domain of the HIF-2α subunit contains a large...

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Detalhes bibliográficos
Main Authors: Scheuermann, Thomas H, Li, Qiming, Ma, He-Wen, Key, Jason, Zhang, Lei, Chen, Rui, Garcia, Joseph A, Naidoo, Jacinth, Longgood, Jamie, Frantz, Doug E, Tambar, Uttam K, Gardner, Kevin H, Bruick, Richard K
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604136/
https://ncbi.nlm.nih.gov/pubmed/23434853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1185
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