New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF

BACKGROUND: Soluble oligomers of amyloid β-protein (Aβ) have been increasingly linked to synaptic dysfunction, tau alteration and neuritic dystrophy in Alzheimer’s disease (AD) and mouse models. There is a great need for assays that quantify Aβ oligomers with high specificity and sensitivity. METHOD...

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Huvudupphovsmän: Yang, Ting, Hong, Soyon, O’Malley, Tiernan, Sperling, Reisa A., Walsh, Dominic M., Selkoe, Dennis J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604133/
https://ncbi.nlm.nih.gov/pubmed/23375565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2012.11.005
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