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Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands

A series of tropane derivatives has been synthesized as lobelane analogues and evaluated for their binding affinity at the vesicular monoamine transporter-2 (VMAT2), and at α4β2* and α7* nicotinic acetylcholine receptors. The trop-2-ene analogues 4a and 4b exhibited good affinity and high selectivit...

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Detalhes bibliográficos
Main Authors: Zheng, Guangrong, Dwoskin, Linda P., Deaciuc, Agripina G., Crooks, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602420/
https://ncbi.nlm.nih.gov/pubmed/16112864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2005.07.032
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