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Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands
A series of tropane derivatives has been synthesized as lobelane analogues and evaluated for their binding affinity at the vesicular monoamine transporter-2 (VMAT2), and at α4β2* and α7* nicotinic acetylcholine receptors. The trop-2-ene analogues 4a and 4b exhibited good affinity and high selectivit...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3602420/ https://ncbi.nlm.nih.gov/pubmed/16112864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2005.07.032 |
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